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Literature summary extracted from

  • Xing, Y.; Chen, J.; Tu, J.; Zhang, B.; Chen, X.; Shi, H.; Baker, S.C.; Feng, L.; Chen, Z.
    The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase (2013), J. Gen. Virol., 94, 1554-1567.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.B50 expressed in HEK-293T cells porcine epidemic diarrhea virus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.B50 C1729A the mutant shows reduced interferon antagonistic activity compared to that of the wild type enzyme porcine epidemic diarrhea virus
3.4.22.B50 D1901A the mutant almost completely loses interferon antagonistic activity compared to that of the wild type enzyme porcine epidemic diarrhea virus
3.4.22.B50 H1888A the mutant almost completely loses interferon antagonistic activity compared to that of the wild type enzyme porcine epidemic diarrhea virus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.B50 ubiquitin + H2O porcine epidemic diarrhea virus the enzyme processes both K-48 and K-63 linked polyubiquitin chains ?
-
 ?
3.4.22.B50 ubiquitinated RIG-I + H2O porcine epidemic diarrhea virus
-
 deubiquitinated RIG-I + ubiquitin
-
 ?
3.4.22.B50 ubiquitinated STING + H2O porcine epidemic diarrhea virus
-
 deubiquitinated STING + ubiquitin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B50 porcine epidemic diarrhea virus P0C6Y4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.B50 ubiquitin + H2O the enzyme processes both K-48 and K-63 linked polyubiquitin chains porcine epidemic diarrhea virus ?
-
 ?
3.4.22.B50 ubiquitinated RIG-I + H2O
-
 porcine epidemic diarrhea virus deubiquitinated RIG-I + ubiquitin
-
 ?
3.4.22.B50 ubiquitinated STING + H2O
-
 porcine epidemic diarrhea virus deubiquitinated STING + ubiquitin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.B50 PLP2
-
 porcine epidemic diarrhea virus

General Information

EC Number General Information Comment Organism
3.4.22.B50 physiological function the enzyme strongly inhibits RIG-Iand STING-activated interferon expression. Papain-like protease 2 acts as a viral deubiquitinase to interfere with the RIG-I- and STING-mediated signalling pathway porcine epidemic diarrhea virus