Literature summary extracted from

Chen, S.; Hu, T.; Zhang, J.; Chen, J.; Chen, K.; Ding, J.; Jiang, H.; Shen, X.
Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease. Crystal structure with molecular dynamics simulations (2008), J. Biol. Chem., 283, 554-564.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.22.69	mutant enzyme G11A and wild-type enzyme are expressed in Escherichia coli	Alphacoronavirus

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
3.4.22.69	crystal structure of monomeric mutant enzyme G11A	Alphacoronavirus

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.22.69	G11A	mutation entirely abolishes activity	Alphacoronavirus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.69	Alphacoronavirus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.4.22.69	-	Alphacoronavirus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.22.69	[4-(4-dimethylaminophenylazo)benzoic acid]-VNSTLQSGLRK-[5-[2'-(aminoethyl)amino]-naphthalenesulfonic acid]-M + H2O	-	Alphacoronavirus	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.69	3cLpro	-	Alphacoronavirus
3.4.22.69	coronavirus 3C-like protease	-	Alphacoronavirus
3.4.22.69	SARS-CoV 3C-like protease	-	Alphacoronavirus

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Release 2023.1 (January 2023)