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Literature summary for 7.6.2.2 extracted from
- P-glycoprotein mediates the collateral sensitivity of multidrug resistant cells to steroid hormones (2014), Biochem. Biophys. Res. Commun., 447, 574-579.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetulus griseus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| CHO cell | - |
Cricetulus griseus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + deoxycorticosterone/in | - |
Cricetulus griseus | ADP + phosphate + deoxycorticosterone/out | - |
? |  |
| ATP + H2O + progesterone/in | - |
Cricetulus griseus | ADP + phosphate + progesterone/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCB1 | - |
Cricetulus griseus |
| P-glycoprotein | - |
Cricetulus griseus |
| P-gp | - |
Cricetulus griseus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | knockdown of enzyme expression reverses progesterone- and deoxycorticosterone-induced collateral sensitivity of CHO cells | Cricetulus griseus |
| physiological function | the enzyme mediates collateral sensitivity of multidrug resistance cells in the presence of physiologically achievable concentrations of progesterone and deoxycorticosterone | Cricetulus griseus |
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Release 2023.1 (January 2023)
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