Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64446 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
enterocyte | - |
Mus musculus | - |
intestine | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | transporter ATP7B maintains a Cu gradient along the duodenal crypt-villus axis and buffers Cu levels in the cytosol of enterocytes, mediated by rapid Cu-dependent enlargement of ATP7B-containing vesicles and increased levels of ATP7B. Intestines of Atp7b-/- mice show reduced Cu storage pools in intestine, Cu depletion, accumulation of triglyceride-filled vesicles in enterocytes, mislocalization of apolipoprotein B, and loss of chylomicrons | Mus musculus |