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Literature summary for 5.6.2.4 extracted from

  • Li, Z.; Yin, S.; Sun, M.; Cheng, X.; Wei, J.; Gilbert, N.; Miao, J.; Cui, L.; Huang, Z.; Dai, X.; Jiang, L.
    DNA helicase RecQ1 regulates mutually exclusive expression of virulence genes in Plasmodium falciparum via heterochromatin alteration (2019), Proc. Natl. Acad. Sci. USA, 116, 3177-3182 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information construction of an enzyme knockout PfRecQ1DELTA strain D3. Deletion of PfRecQ1 increases the heterochromatin mark trimethylated (H3K9me3) at the transcription start site (TSS) of the var gene upsC1, that deletion has no effect on the global distribution of H3K9me3 over gene bodies, including those for the var genes. Upon PfRecQ1 deletion, the upsC1 var gene moves from the active perinuclear transcription region to a silenced region of the upsC type, implying that PfRecQ1, but not PfWRN, is essential for maintaining the clonal expression of var genes Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
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-
-
Plasmodium falciparum 3D7C8
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-
-

Synonyms

Synonyms Comment Organism
DNA helicase
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 Plasmodium falciparum
RecQ1
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 Plasmodium falciparum

General Information

General Information Comment Organism
malfunction PfRecQ1enzyme knockout completely abolishes expression of the var gene family. The PfRecQ1DELTA mutation alters heterochromatin, overview Plasmodium falciparum
metabolism expression of the var gene family is regulated by two RecQ DNA helicase family members, PfRecQ1 and PfWRN, in Plasmodium falciparum. PfRecQ1, but not PfWRN, is essential for maintaining the clonal expression of var genes. PfRecQ1 and PfWRN display disparate chromosomal localizations Plasmodium falciparum
physiological function DNA helicase RecQ1 regulates mutually exclusive expression of virulence genes in Plasmodium falciparum via heterochromatin alteration Plasmodium falciparum