Literature summary for 5.6.2.4 extracted from

Dixon, E.P.; Pahel, G.L.; Rocque, W.J.; Barnes, J.A.; Lobe, D.C.; Hanlon, M.H.; Alexander, K.A.; Chao, S.F.; Lindley, K.; Phelps, W.C.
The E1 helicase of human papillomavirus type 11 binds to the origin of replication with low sequence specificity (2000), Virology, 270, 345-357.

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Protein Variants

Protein Variants	Comment	Organism
D523N	DNA binding and ATPase activity is comparable to wild-type enzyme, no in vitro replication activity	human papillomavirus 11
D542N	DNA binding and ATPase activity is comparable to wild-type enzyme, no in vitro replication activity	human papillomavirus 11
K484E	mutant enzyme binds the immunoaffinity column poorly, the heparin purified E1/K484E is tested for the above activities. The protein that is recovered shows no activity	human papillomavirus 11
P479S	DNA binding and ATPase activity is comparable to wild-type enzyme, 50% of in vitro replication activity compared to wild-type enzyme	human papillomavirus 11

Organism

Organism	UniProt	Comment	Textmining
human papillomavirus 11	P04014	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	-	human papillomavirus 11	ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
E1 helicase	-	human papillomavirus 11

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Release 2023.1 (January 2023)