Any feedback?
Literature summary for 5.6.2.4 extracted from
- Roles of the Werner syndrome RecQ helicase in DNA replication (2008), DNA Repair, 7, 1776-1786.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| replication protein A | stimulates helicase activity | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Homo sapiens | 3'-5' helicase activity. WRN helicase is involved in preserving DNA integrity during replication. It is proposed that WRN helicase can function in coordinating replication fork progression with replication stress-induced fork remodeling | ADP + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q14191 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | 3'-5' helicase activity. WRN helicase is involved in preserving DNA integrity during replication. It is proposed that WRN helicase can function in coordinating replication fork progression with replication stress-induced fork remodeling | Homo sapiens | ADP + phosphate | - |
? | |
| ATP + H2O | 3'-5' helicase activity | Homo sapiens | ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Werner syndrome RecQ helicase | - |
Homo sapiens |
| WRN helicase | - |
Homo sapiens |
| WRN protein | - |
Homo sapiens |
| WRN RecQ helicase | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
