Literature summary for 5.6.2.3 extracted from

Khan, I.; Crouch, J.D.; Bharti, S.K.; Sommers, J.A.; Carney, S.M.; Yakubovskaya, E.; Garcia-Diaz, M.; Trakselis, M.A.; Brosh, R.M.
Biochemical characterization of the human mitochondrial replicative twinkle helicase substrate specificity, DNA branch migration, and ability to overcome blockades to DNA unwinding (2016), J. Biol. Chem., 291, 14324-14339 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
mitochondrial transcription factor A	171 or 342 nM completely inhibit helicase activity	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	although the enzyme behaves as a traditional 5' to 3' helicase on conventional forked duplex substrates, fuelled by the hydrolysis of nucleoside triphosphate, it efficiently dissociates D-loop DNA substrates irrespective of whether it possesses a 5' or 3' single-stranded tailed invading strand. In contrast, the enzyme branch-migrates an open-ended mobile three-stranded DNA structure with a strong 5' to 3' directionality preference. The enzyme can load onto single-stranded DNA circles or double-stranded DNA bubble structures, and it binds both single-stranded and double-stranded DNA	Homo sapiens	?	-	-

Synonyms

Synonyms	Comment	Organism
C10orf2	-	Homo sapiens
mitochondrial DNA replicative helicase Twinkle	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme is an essential player in mitochondrial DNA replication	Homo sapiens

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Release 2023.1 (January 2023)