Literature summary for 5.6.2.3 extracted from

Khan, I.; Suhasini, A.N.; Banerjee, T.; Sommers, J.A.; Kaplan, D.L.; Kuper, J.; Kisker, C.; Brosh, R.M.
Impact of age-associated cyclopurine lesions on DNA repair helicases (2014), PLoS One, 9, e113293.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(5'R)-8,5'-cyclo-2'-deoxyguanosine	the enzyme is strongly inhibited by (5'R)-8,5'-cyclo-2'-deoxyguanosine in the non-translocating strand	Thermoplasma acidophilum
(5'S)-8,5'-cyclo-2'-deoxyguanosine	the enzyme is strongly inhibited by (5'S)-8,5'-cyclo-2'-deoxyguanosine in the non-translocating strand. At 40 nM enzyme, less than 10% of the forked duplex with (5'S)-8,5'-cyclo-2'-deoxyguanosine in the nontranslocating strand is unwound compared to 60% of the control forked duplex or the substrate with (5'S)-8,5'-cyclo-2'-deoxyguanosine in the translocating strand	Thermoplasma acidophilum

Organism

Organism	UniProt	Comment	Textmining
Thermoplasma acidophilum	Q9HM14	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	utilizes the energy from ATP hydrolysis to unwind DNA with 5' to 3' polarity	Thermoplasma acidophilum	ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
XDP	-	Thermoplasma acidophilum

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Release 2023.1 (January 2023)