Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.3 extracted from

  • Rudolf, J.; Rouillon, C.; Schwarz-Linek, U.; White, M.F.
    The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway (2009), Nucleic Acids Res., 38, 931-941.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.3

Inhibitors

Inhibitors Comment Organism Structure
double-strand DNA binding protein
-
 Sulfolobus acidocaldarius
single-strand DNA binding protein
-
 Sulfolobus acidocaldarius

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Sulfolobus acidocaldarius can unwind a bubble substrate consistent with a role in nucleotide excision repair ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Sulfolobus acidocaldarius
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sulfolobus acidocaldarius

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O can unwind a bubble substrate consistent with a role in nucleotide excision repair Sulfolobus acidocaldarius ADP + phosphate
-
 ?
ATP + H2O DNA substrates with overhangs of 0, 6 or 9 nucleotides are unwound at similar rates and remain only partially unwound at the end of the reaction. Overhangs of 12, 15 or 20 nucleotides are unwound progressively more quickly and to completion. XPD can overcome single backbone or base modifications in both the translocated and the displaced strand. It can unwind DNA containing the bulky extrahelical adduct fluorescein and a cyclopyrimidine dimer Sulfolobus acidocaldarius ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
helicase XPD
-
 Sulfolobus acidocaldarius