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Literature summary for 5.6.2.3 extracted from

  • Rudolf, J.; Makrantoni, V.; Ingledew, W.J.; Stark, M.J.; White, M.F.
    The DNA repair helicases XPD and FancJ have essential iron-sulfur domains (2006), Mol. Cell., 23, 801-808.
    View publication on PubMed
Search for more literature for 5.6.2.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Sulfolobus acidocaldarius

Protein Variants

Protein Variants Comment Organism
A349P mutation destabilizes the Fe-S cluster and abolishes helicase activity Sulfolobus acidocaldarius
C105S mutant enzyme contains no Fe-S cluster, complete loss of helicase activity Sulfolobus acidocaldarius
C137S mutant enzyme contains no Fe-S cluster Sulfolobus acidocaldarius
C88S mutant enzyme contains no Fe-S cluster, complete loss of helicase activity Sulfolobus acidocaldarius
R112H mutation destabilizes the Fe-S cluster and abolishes helicase activity Sulfolobus acidocaldarius

Metals/Ions

Metals/Ions Comment Organism Structure
Iron-sulfur cluster
-
 Sulfolobus acidocaldarius
Iron-sulfur cluster is essential for the helicase activity Sulfolobus acidocaldarius

Organism

Organism UniProt Comment Textmining
Sulfolobus acidocaldarius
-
-
-
Sulfolobus acidocaldarius Q4JC68
-
-
Sulfolobus acidocaldarius DSM 639
-
-
-
Sulfolobus acidocaldarius DSM 639 Q4JC68
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O ATP-dependent 5'–3' DNA helicases, DNA-dependent ATPase Sulfolobus acidocaldarius ADP + phosphate
-
 ?
ATP + H2O ATP-dependent 5'–3' DNA helicases, DNA-dependent ATPase Sulfolobus acidocaldarius DSM 639 ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DNA repair helicase FancJ
-
 Sulfolobus acidocaldarius
DNA repair helicases XPD
-
 Sulfolobus acidocaldarius
Saci_0192 locus name Sulfolobus acidocaldarius