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Literature summary for 5.6.2.3 extracted from
- Human coronavirus 229E nonstructural protein 13: characterization of duplex-unwinding, nucleoside triphosphatase, and RNA 5-triphosphatase activities (2004), J. Virol., 78, 7833-7838.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no stimulation by poly(G) | Human coronavirus 229E | |
| poly(C) | strong stimulation | Human coronavirus 229E |  |
| poly(dA) | strong stimulation | Human coronavirus 229E | |
| Poly(dT) | strong stimulation | Human coronavirus 229E | |
| Poly(U) | strong stimulation | Human coronavirus 229E | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| baculovirus expression system | Human coronavirus 229E |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human coronavirus 229E | P0C6X1 | replicase polyprotein 1ab | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Human coronavirus 229E |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | the recombinant protein has both RNA and DNA duplex-unwinding activities with 5'-to-3' polarity. The DNA helicase activity of the enzyme preferentially unwinds 5'-oligopyrimidine-tailed, partial-duplex substrates and requires a tail length of at least 10 nucleotides for effective unwinding | Human coronavirus 229E | ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HCoV helicase | - |
Human coronavirus 229E |
| HCoV SF1 helicase | - |
Human coronavirus 229E |
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Release 2023.1 (January 2023)
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