Protein Variants | Comment | Organism |
---|---|---|
P1G | inactive | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-dopachrome | Homo sapiens | - |
5,6-dihydroxyindole-2-carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14174 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B cell | - |
Homo sapiens | - |
dendritic cell | - |
Homo sapiens | - |
eosinophil | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
intestine | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
serum | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-dopachrome | - |
Homo sapiens | 5,6-dihydroxyindole-2-carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
macrophage inhibitory factor | - |
Homo sapiens |
MIF | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is induced by low levels of glucocorticoids in vitro and in vivo | up |
General Information | Comment | Organism |
---|---|---|
malfunction | a tautomerase-null protein shows reduced binding affinity to the receptors CD74 and CXCR2, and an impaired ability to induce ERK1/2 MAP kinase activation. Cells expressing the tautomerase-null protein show reduced proliferative capacity, and enzyme-deficient mice show a reduced development in benzo[a]pyrene-induced skin tumors. | Homo sapiens |
physiological function | the enzyme inhibits the migration of macrophages. The enzyme activates the MAP kinase cascade, modulates cell migration, and counter-acts the immunosuppressive effects of glucocorticoids. For many cell types, the enzyme also acts as an important survival or anti-apoptotic factor. the enzyme is essential for the production of pro-inflammatory mediators such as tissue necrosis factor alpha, interleukin-1beta, prostaglandin E2 and nitric oxide by macrophages. The enzyme is necessary for maximal c-jun-N-terminal kinase-dependent AP-1 transactivation and subsequent CXCL8 and VEGF transcription in human lung adenocarcinoma cells | Homo sapiens |