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Literature summary for 3.6.4.B9 extracted from

  • Mason, J.M.; Dusad, K.; Wright, W.D.; Grubb, J.; Budke, B.; Heyer, W.D.; Connell, P.P.; Weichselbaum, R.R.; Bishop, D.K.
    RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells (2015), Nucleic Acids Res., 43, 3180-3196 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.B9

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92698
-
-
Homo sapiens Q9Y620
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibrosarcoma cell
-
 Homo sapiens
-
HT-1080 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DNA repair and recombination protein RAD54-like UniProt Homo sapiens
DNA repair and recombination protein RAD54B UniProt Homo sapiens
RAD54B
-
 Homo sapiens
RAD54L
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction combined depletion of RAD54L and RAD54B and/or artificial induction of RAD51 overexpression blocks replication and promotes chromosome segregation defects. RAD54 translocase depletion increases RAD51 focus formation in MCF7 cells Homo sapiens
physiological function the mammalian translocases, RAD54L and RAD54B, function to prevent the accumulation of nondamage-associated RAD51 complexes. RAD54L and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in human tumor cells. RAD54 been shown to remove RAD51 from dsDNA, it has also been reported to stabilize the interaction of RAD51 with ssDNA in vitro by a process that does not require ATP hydrolysis. RAD54 family translocases prevent accumulation of nondamage-associated RAD51 complexes in MCF-7 cells Homo sapiens
physiological function the mammalian translocases, RAD54L and RAD54B, function to prevent the accumulation of nondamage-associated RAD51 complexes. RAD54L and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in human tumor cells. RAD54 removes RAD51 from dsDNA, it has also been reported to stabilize the interaction of RAD51 with ssDNA in vitro by a process that does not require ATP hydrolysis. RAD54 family translocases prevent accumulation of nondamage-associated RAD51 complexes in MCF-7 cells Homo sapiens