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Literature summary for 3.6.1.7 extracted from

  • Degl'Innocenti, D.; Ramazzotti, M.; Sarchielli, E.; Monti, D.; Chevanne, M.; Vannelli, G.B.; Barletta, E.
    Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells a possible role in neurotoxicity (2019), Toxicology, 411, 110-121 .
    View publication on PubMed
Search for more literature for 3.6.1.7

Cloned(Commentary)

Cloned (Comment) Organism
gene ACYP2, relative RNA expression level of ACYP in HSP cells is determined by real-time reverse transcription PCR Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme silencing (99%) by ACYP2 siRNA-transfected HSP cells. Polymorphisms in ACYP2 gene are associated with oxaliplatin-induced neurotoxicity and with altered telomere length/dysfunction Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylphosphate + H2O Homo sapiens
-
 acetate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14621
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corpus striatum
-
 Homo sapiens
-
corpus striatum human primary striatal neuronal precursor cell, HSP. Relative RNA expression level of ACYP in HSP cells is determined by real-time reverse transcription PCR. No expression of isozyme ACYP1 Homo sapiens
-
fibroblast increased levels of ACYP have been revealed in fibroblasts from patients affected by Alzheimer's disease Homo sapiens
-
neuron primary neuronal precursor cells isolated from human striatal primordium Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylphosphate + H2O
-
 Homo sapiens acetate + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 11000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ACYP2
-
 Homo sapiens
muscle-type acylphosphatase 2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens oxadiazon, a pre-emergence or early post-emergence herbicide, induces ACYP2 expression in HSP cells up

General Information

General Information Comment Organism
evolution two isoforms of ACYP are characterized, the erythrocyte-type acylphosphatase 1 (ACYP1) and the muscle-type acylphosphatase 2 (ACYP2) Homo sapiens
malfunction upon inhibition of ACYP2 gene by siRNA, exposure to oxadion, that induces the ACYP2 gene, is no more able to exert an inhibitory effect on both neuritogenesis and on GAP43 protein expression stimulated by FGF2 or BDNF. The motility of HSP cells transfected with ACYP2 siRNA is tested by the scratch wound healing assay, exposure to oxadion fails to retard the closure of the wound, and cell-free area is quite completely closed after 24 h as observed in control untransfected cells grown in absence of oxadion. Polymorphisms in ACYP2 gene are associated with oxaliplatin-induced neurotoxicity and with altered telomere length/dysfunction. ACYP2 is a molecular target of neurotoxicity Homo sapiens
physiological function increased levels of ACYP have been revealed in fibroblasts from patients affected by Alzheimer's diseas. ACYP2 is involved in ion transport, cell differentiation, programmed cell death, and cancer Homo sapiens