Cloned (Comment) | Organism |
---|---|
functional expression of enzyme in HT1080 cells and U251 glioma cells, leading to enhanced levels of pro-matrix metalloprotease-2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fibronectin | protects the cell surface tissue transglutaminase against degradation by MT1 MMP | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | on the cell surface | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
x * 42000, MT1 MMP ectodomain, SDS-PAGE, x * 60000, MT1 MMP, active enzyme, SDS-PAGE | Homo sapiens |
60000 | - |
x * 42000, MT1 MMP ectodomain, SDS-PAGE, x * 60000, MT1 MMP, active enzyme, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cell surface tissue transglutaminase + H2O | Homo sapiens | regulation of cancer cell adhesion, degradation supresses specifically cell adhesion and migration on fibronectin, but stimulates migration of cells on collagen | ? | - |
? | |
protein + H2O | Homo sapiens | - |
peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50281 | membrane-type-1, -type -2 and -type-3 matrix metalloproteases | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-1080 cell | low expression level | Homo sapiens | - |
U-251 cell | low expression level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cell surface tissue transglutaminase + H2O | at the leading edge of motile cancer cells, membrane-type-1, -type -2 and -type-3 matrix metalloproteases | Homo sapiens | 4 major and several minor cleavage products of cell surface tissue transglutaminase | - |
? | |
cell surface tissue transglutaminase + H2O | regulation of cancer cell adhesion, degradation supresses specifically cell adhesion and migration on fibronectin, but stimulates migration of cells on collagen | Homo sapiens | ? | - |
? | |
progelatinase A + H2O | substrate is activated by cleavage | Homo sapiens | gelatinase A + ? | - |
? | |
protein + H2O | - |
Homo sapiens | peptides | - |
? | |
protein + H2O | enzyme is involved in breakdown of extracellular matrix | Homo sapiens | peptides | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 42000, MT1 MMP ectodomain, SDS-PAGE, x * 60000, MT1 MMP, active enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
M10.015 | Merops-ID | Homo sapiens |
membrane-type matrix metalloproteinase | - |
Homo sapiens |
membrane-type-1 matrix metalloproteinase | - |
Homo sapiens |
membrane-type-2 matrix metalloproteinase | - |
Homo sapiens |
membrane-type-3 matrix metalloproteinase | - |
Homo sapiens |
MT MMP | - |
Homo sapiens |
MT1 MMP | - |
Homo sapiens |
MT2 MMP | - |
Homo sapiens |
MT3 MMP | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |