Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ALS 1-0635 | noncompetitive | Bos taurus | |
ALS 1-0635 | noncompetitive | Homo sapiens | |
ALS 1-0635 | noncompetitive | Rattus norvegicus | |
ilomastat | a broad-spectrum MMP inhibitor | Bos taurus | |
ilomastat | a broad-spectrum MMP inhibitor | Homo sapiens | |
additional information | development of MMP-13 inhibitors mechanistically distinct from previously reported broad-spectrum MMP inhibitors with improved selectivity and pharmacokinetics. Chondroprotective effect of MMP-13-selective inhibitors | Bos taurus | |
additional information | development of MMP-13 inhibitors mechanistically distinct from previously reported broad-spectrum MMP inhibitors with improved selectivity and pharmacokinetics. Chondroprotective effect of MMP-13-selective inhibitors | Homo sapiens | |
additional information | development of MMP-13 inhibitors mechanistically distinct from previously reported broad-spectrum MMP inhibitors with improved selectivity and pharmacokinetics. Chondroprotective effect of MMP-13-selective inhibitors. Effect of MMP-13 inhibition on cartilage degradation in the rat medial meniscal tear model of osteoarthritis, overview | Rattus norvegicus | |
Ro32-3555 | a broad-spectrum MMP inhibitor | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | steady-state kinetics analysis, overview | Homo sapiens | |
additional information | - |
additional information | steady-state kinetics analysis, overview | Rattus norvegicus | |
additional information | - |
additional information | steady-state kinetics analysis, overview | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular matrix | - |
Homo sapiens | 31012 | - |
extracellular matrix | - |
Rattus norvegicus | 31012 | - |
extracellular matrix | - |
Bos taurus | 31012 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | MMP-13 causes cartilage degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
male Sprague-Dawley IGS rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | articular | Bos taurus | - |
cartilage | of knee meniscus | Rattus norvegicus | - |
cartilage | osteoarthritic | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
MCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH2 + H2O | - |
Homo sapiens | ? | - |
? | |
MCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
MCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH2 + H2O | - |
Bos taurus | ? | - |
? | |
additional information | MMP-13 causes cartilage degradation | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase 13 | - |
Homo sapiens |
matrix metalloproteinase 13 | - |
Rattus norvegicus |
matrix metalloproteinase 13 | - |
Bos taurus |
MMP-13 | - |
Homo sapiens |
MMP-13 | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Rattus norvegicus |
7.5 | - |
assay at | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000078 | - |
ALS 1-0635 | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00000078 | - |
ALS 1-0635 | pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | |
0.00000078 | - |
ALS 1-0635 | pH not specified in the publication, temperature not specified in the publication | Bos taurus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | interleukin-1 and oncostatin M induce MMP-13 expression | up |
Rattus norvegicus | interleukin-1 and oncostatin M induce MMP-13 expression | up |
Bos taurus | interleukin-1 and oncostatin M induce MMP-13 expression | up |