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Literature summary for 3.4.24.B12 extracted from
- Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis (2011), J. Biol. Chem., 286, 34298-34310.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| dermal fibroblast | strong expression | Mus musculus | - |
| skin | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| versican + H2O | cleaves versican at Glu441-Ala442 within the glycosaminoglycan beta region of versican V1 | Mus musculus | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS5 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | ADAMTS5 deficient mice have reduced versican proteolysis, increased pericellular matrix, altered cell shape, enhanced alpha-smooth muscle actin expression and increased contractility within three dimensional collagen gels | Mus musculus |
| physiological function | ADAMTS5 maintains optimal versican content and pericellular matrix volume by continually trimming versican in hyaluronan-versican aggregates | Mus musculus |
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Release 2023.1 (January 2023)
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