Literature summary for 3.4.24.B11 extracted from

Noriega-Guerra, H.; Cruz, M.C.; Ribeiro, P.R.L.; Strnadel, J.; Wang, H.; Klemke, R.L.; Jaeger, R.G.; Freitas, V.M.
ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma (2018), Exp. Cell Res., 363, 271-282 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
HT-1080 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	HT-1080 cells overexpressing ADAMTS-1 exhibit a significant decrease in cell proliferation and migration velocity, both in presence of hepatocyte growth factor. ADAMTS-1 overexpression disturbs c-Met activation upon hepatocyte growth factor stimulation. Downstream ERK1/2 and FAK signaling pathways are also influenced. ADAMTS-1 decreases the size of the fibrosarcospheres, both under normal conditions and in the presence of hepatocyte growth factor. In presence of hepatocyte growth factor, ADAMTS-1 overexpression in HT-1080 disrupts microtumors formation in vivo	Homo sapiens

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Release 2023.1 (January 2023)