Cloned (Comment) | Organism |
---|---|
ADAMTS-4 and ADAMTS-5 | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BB-16 | 0.1 mM, complete inhibition of aggrecanase 1 and 2 | Bos taurus | |
EDTA | 1 mM, complete inhibition of aggrecanase 1 and 2 | Bos taurus | |
o-phenanthroline | 1 mM, complete inhibition of aggrecanase 1 and 2 | Bos taurus | |
SE206 | 0.1 mM, complete inhibition of aggrecanase 1 and 2 | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.48 | - |
QTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLK | biotinylated peptide containing aggrecanase cleavage site | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
aggrecanase-1 and 2, i.e. ADAMTS-4 and 5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | cartilage culture | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
QTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLK + H2O | - |
Bos taurus | QTVTWPDMELPLPRNITEGE + ARGSVILTVKPIFEVSPSPLK | - |
? |