Cloned (Comment) | Organism |
---|---|
ECE-1 is endogenously expressed in HMEC-1 cells (RT-PCR, immunofluorescence) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-chloro-N-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)carbonyl)benzenesulfonamide | - |
Homo sapiens | |
4-chloro-N-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)carbonyl)benzenesulfonamide | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 | ECE-1 regulates re-sensitization of substance P signalling in HMEC-1-NK1 receptor cells | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ear | ECE-1 promotes re-sensitization of SP-induced inflammation | Rattus norvegicus | - |
HMEC-1 cell | - |
Homo sapiens | - |
skin | dorsal skin, ECE-1 promotes re-sensitization of SP-induced inflammation | Rattus norvegicus | - |
urinary bladder | ECE-1 promotes re-sensitization of SP-induced inflammation | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
endothelin-converting enzyme 1 (ECE-1) | - |
Homo sapiens |
endothelin-converting enzyme 1 (ECE-1) | - |
Rattus norvegicus |