Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-(8[(1R,3S,4aR,8aS)-1-[[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal | - |
Severe acute respiratory syndrome-related coronavirus | |
(2S)-2-([(1R,3R,4aR,8aS)-1-8[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal | - |
Severe acute respiratory syndrome-related coronavirus | |
(2S)-2-([[(1S,3R,4aR,8aS)-1-[[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal | - |
Severe acute respiratory syndrome-related coronavirus | |
(2S)-2-([[(1S,3S,4aR,8aS)-1[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methylamino)-3-(1H-imidazol-4-yl)propanal | - |
Severe acute respiratory syndrome-related coronavirus | |
(2S)-2-([[(1S,4aR,8aS)-1-[[benzyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal | - |
Severe acute respiratory syndrome-related coronavirus | |
(2S)-2-([[(1S,4aR,8aS)-1-[[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal | - |
Severe acute respiratory syndrome-related coronavirus | |
(2S)-3-(1H-imidazol-4-yl)-2-([[(1S,4aR,8aS)-1-[[methyl(prop-2-en-1-yl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)propanal | - |
Severe acute respiratory syndrome-related coronavirus | |
(S)-2-((((1S,3R,4aR,8aS)-1-((butyl(methyl)amino)methyl)octahydro-1H-isochromen-3-yl)methyl)amino)-3-(1H-imidazol-4-yl)propanal | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | P0C6X7 | human, i.e. SARS-CoV | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SARS 3CLpro | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.095 | - |
pH 7.5, 37°C, mutant enzyme R188I | Severe acute respiratory syndrome-related coronavirus | (2S)-2-([[(1S,3S,4aR,8aS)-1[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methylamino)-3-(1H-imidazol-4-yl)propanal | |
0.1 | - |
pH 7.5, 37°C, mutant enzyme R188I | Severe acute respiratory syndrome-related coronavirus | (2S)-2-([[(1S,4aR,8aS)-1-[[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal | |
0.26 | - |
pH 7.5, 37°C, mutant enzyme R188I | Severe acute respiratory syndrome-related coronavirus | (2S)-2-([[(1S,3R,4aR,8aS)-1-[[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal | |
0.42 | - |
pH 7.5, 37°C, mutant enzyme R188I | Severe acute respiratory syndrome-related coronavirus | (2S)-3-(1H-imidazol-4-yl)-2-([[(1S,4aR,8aS)-1-[[methyl(prop-2-en-1-yl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)propanal | |
0.42 | - |
pH 7.5, 37°C, mutant enzyme R188I | Severe acute respiratory syndrome-related coronavirus | (2S)-2-([[(1S,4aR,8aS)-1-[[benzyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal | |
0.44 | - |
pH 7.5, 37°C, mutant enzyme R188I | Severe acute respiratory syndrome-related coronavirus | (2S)-2-(8[(1R,3S,4aR,8aS)-1-[[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal | |
0.78 | - |
pH 7.5, 37°C, mutant enzyme R188I | Severe acute respiratory syndrome-related coronavirus | (2S)-2-([(1R,3R,4aR,8aS)-1-8[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal |