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Literature summary for 3.4.22.53 extracted from

  • Ahmad, F.; Das, D.; Kommaddi, R.P.; Diwakar, L.; Gowaikar, R.; Rupanagudi, K.V.; Bennett, D.A.; Ravindranath, V.
    Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimers disease mice and correlates with memory deficits in human subjects (2018), Sci. Rep., 8, 13119 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus O08529 calcpain-2, catalytic subunit
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Source Tissue

Source Tissue Comment Organism Textmining
brain isoform-specific hyperactivation of calpain-2, but not calpain-1 occurs at the synapse early in the pathogenesis of Alzheimer's disease potentially contributing to the deregulation of synaptic signaling in Alzheimer's disease Mus musculus
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General Information

General Information Comment Organism
metabolism isoform-specific hyperactivation of calpain-2, but not calpain-1 occurs at the synapse early in the pathogenesis of Alzheimer's disease potentially contributing to the deregulation of synaptic signaling in Alzheimer's disease Mus musculus