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Literature summary for 3.4.22.52 extracted from

  • Randriamboavonjy, V.; Kyselova, A.; Elgheznawy, A.; Zukunft, S.; Wittig, I.; Fleming, I.
    Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice (2017), Basic Res. Cardiol., 112, 10 .
    View publication on PubMed
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Application

Application Comment Organism
medicine since calpain inhibition prevents diabetes-induced endothelial dysfunction in mesenteric arteries. Calpains represent an interesting therapeutic target for the prevention of cardiovascular complication of diabetes Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prostacyclin synthase + H2O Mus musculus calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice. It cleaves the C-terminal domain of PGI2 synthase close to the catalytic site of the enzyme ?
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Organism

Organism UniProt Comment Textmining
Mus musculus O35350 calpain-1 catalytic subunit
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostacyclin synthase + H2O calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice. It cleaves the C-terminal domain of PGI2 synthase close to the catalytic site of the enzyme Mus musculus ?
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 ?