Literature summary for 3.4.22.52 extracted from

  • Ma, H.; Tochigi, A.; Shearer, T.R.; Azuma, M.
    Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells (2009), J. Ocul. Pharmacol. Ther., 25, 409-414.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine manipulating calpain activity by calpain inhibitor SNJ-1945 is a therapy for management of pathological angiogenesis, such as that occurring in proliferative retinopathy and age-related macular degeneration with neovascularization Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SNJ-1945
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal microvascular endothelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-spectrin + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
mu-calpain
-
Homo sapiens
calpain 1
-
Homo sapiens