Literature summary for 3.4.22.52 extracted from

  • Liu, L.; Xing, D.; Chen, W.R.
    Micro-calpain regulates caspase-dependent and apoptosis inducing factor-mediated caspase-independent apoptotic pathways in cisplatin-induced apoptosis (2009), Int. J. Cancer, 125, 2757-2766.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
calpeptin
-
Homo sapiens
PD150606
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
lung adenocarcinoma cell
-
Homo sapiens
-
ASTC-a-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apoptosis-inducing factor + H2O micro-calpain mediates the truncation and release of apoptosis-inducing factor from mitochondria following cisplatin treatment Homo sapiens ?
-
?
N-acetyl-LLY-7-amido-4-fluoromethylcoumarin + H2O
-
Homo sapiens N-acetyl-LLY + 7-amino-4-fluoromethylcoumarin
-
?

Synonyms

Synonyms Comment Organism
micro-calpain
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens after cisplatin treatment, calpain activation is an early event up

General Information

General Information Comment Organism
physiological function activation of micro-calpain plays an essential role in regulating both caspase-dependent and apoptosis-inducing factor-mediated caspase-independent apoptotic pathways in cisplatin-induced apoptosis Homo sapiens
malfunction inhibition of micro-calpain not only significantly reduces caspase-9/-3 activities but also completely blocks apoptosis-inducing factor redistribution Homo sapiens