Literature summary for 3.4.22.52 extracted from

  • Supinski, G.S.; Callahan, L.A.
    Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction (2010), Am. J. Respir. Cell Mol. Biol., 42, 80-87.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
endotoxin treatment with 12 mg/kg endotoxin increases diaphragm calpain activity and active calpain I protein Mus musculus

Application

Application Comment Organism
medicine calpain inhibition attenuates endotoxin-induced diaphragm weakness, suggesting that such inhibitors may be a potential treatment to improve respiratory function in infected patients Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
calpain inhibitor peptide III
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
talin + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
diaphragm
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
talin + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
calpain I
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus treatment with 12 mg/kg endotoxin increases active calpain I protein up