Literature summary for 3.4.22.15 extracted from

Cao, Y.; Liu, X.; Li, Y.; Lu, Y.; Zhong, H.; Jiang, W.; Chen, A.F.; Billiar, T.R.; Yuan, H.; Cai, J.
Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans (2017), Int. Urol. Nephrol., 49, 1409-1417 .

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Application

Application	Comment	Organism
diagnostics	specificity and sensitivity of cathepsin L activity is a diagnostic biomarker for proteinuria	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07711	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	high expression level in chronic kidney disease (CKD)	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	the cysteine protease cathepsin L is a matrix-degrading enzyme known to be increased in chronic inflammation. Cathepsin L is highly expressed in the foot processes of podocytes in the kidney, which serves as an ultrafiltration barrier. It contributes to glomerular filtration barrier dysfunction through enhanced production of reactive oxygen species and the cleavage of the large GTPase dynamin as well as synaptopodin in podocytes. Cathepsin L is also upregulated in the setting of inflammation as a feature of chronic kidney disease (CKD). Proteinuria severity in CKD patients might correlate with increased serum levels of cathepsin L. Long-term increased tubular protein load further increases cathepsin L activity in the proximal tubule and degrades tubular protein in the progression of CKD. Patients with severe proteinuria have a higher cathepsin L activity compared to those with moderate or mild proteinuria. Association between serum cathepsin L activity and biochemical indicators, overview	Homo sapiens

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Release 2023.1 (January 2023)