Cloned (Comment) | Organism |
---|---|
expressed in PC-12 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | cathepsin L knock-out mice show major decreases in adrenocorticotropic hormone, beta-endorphin, and alpha-melanocyte stimulating hormone in pituitary, accompanied by increased levels of proopiomelanocortin | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CLIK-148 | treatment of AtT-20 cells results in reduced production of adrenocorticotropic hormone and accumulation of proopiomelanocortin | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
vesicular fraction | - |
Mus musculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | - |
SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | cathepsin L has a prominent role in the production of adrenocorticotropic hormone, beta-endorphin, and alpha-melanocyte stimulating hormone | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | P06797 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AtT-20 cell | treatment with inhibitor CLIK-148 results in reduced production of adrenocorticotropic hormone and accumulation of proopiomelanocortin | Mus musculus | - |
brain | - |
Mus musculus | - |
pituitary gland | colocalization of cathepsin L with beta-endorphin and alpha-melanocyte stimulating hormone in the intermediate pituitary and with adrenocorticotropic hormone in the anterior pituitary. Partial colocalization with lysosomal marker Lamp-1 adrenocorticotropic hormone | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
additional information | cathepsin L has a prominent role in the production of adrenocorticotropic hormone, beta-endorphin, and alpha-melanocyte stimulating hormone | Mus musculus | ? | - |
? | |
pro-neuropeptide Y + H2O | cathepsin L cleaves pro-neuropeptide Y (1-70) to generate neuropeptide Y-Gly (1-38) and the COOH-terminal peptide fragment (39-70) | Mus musculus | neuropeptide Y + ? | - |
? |