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Literature summary for 3.4.22.1 extracted from

  • Li, S.; Du, L.; Zhang, L.; Hu, Y.; Xia, W.; Wu, J.; Zhu, J.; Chen, L.; Zhu, F.; Li, C.; Yang, S.
    Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line (2013), J. Biol. Chem., 288, 30094-30104.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
INS-1 cell
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 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
cathepsin B
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 Rattus norvegicus
CTSB
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 Rattus norvegicus

General Information

General Information Comment Organism
malfunction blocking CTSB expression using CTSB siRNA suppresses inflammatory response but does not affect apoptosis markedly Rattus norvegicus
physiological function Atg7-induced CTSB overexpression contributes to an NLRP3-dependent proinflammatory response and subsequently impairs glucose-stimulated insulin secretion independently of apoptosis Rattus norvegicus