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Literature summary for 3.4.22.1 extracted from

  • Colin, C.; Voutsinos-Porche, B.; Nanni, I.; Fina, F.; Metellus, P.; Intagliata, D.; Baeza, N.; Bouvier, C.; Delfino, C.; Loundou, A.; Chinot, O.; Lah, T.; Kos, J.; Martin, P.M.; Ouafik, L.; Figarella-Branger, D.
    High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas (2009), Acta Neuropathol., 118, 745-754.
    View publication on PubMed
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Application

Application Comment Organism
diagnostics cathepsin B is an important biomarker for the stratification of glioblastoma patients with respect to survival Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
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 Homo sapiens
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glioblastoma cell the most frequent malignant brain tumor in adults, increased expression of cathepsin B compared to healthy astrocytes, immunohistochemic and expression analysis, overview Homo sapiens
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General Information

General Information Comment Organism
malfunction cathepsin B overexpression in glioblastoma is correlated with a short survival of the patient Homo sapiens
physiological function proteases play a major role in the invasion process with correlations between glioma grading, survival and protease expression. Cathepsin B is involved in extracellular matrix degradation in glioblastomas, and in invasion and angiogenesis, overview Homo sapiens