Application | Comment | Organism |
---|---|---|
additional information | proteolytic mechanism for prostasin to intercept cytokine signaling during bacterial lipopolysaccharide-induced bladder inflammation | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in Mus musculus urinary bladder epithelium | Homo sapiens |
into vector pREP8, expression in the bladder of transgenic mice | Homo sapiens |
subcloned into the pREP8 plasmid, transfected into the HEK-293 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | prostasin mutant does not manifest the nitric oxide synthase induction attenuation phenotype | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bacterial lipopolysaccharide | viral promoter-driven expression of the human prostasin in the bladder of transgenic mice attenuates the bacterial lipopolysaccharide induction of nitric oxide synthase, whereas induction of cyclooxygenase-2, TNF-alpha, IL-1beta and IL-6 expression is not reduced | Homo sapiens | |
bacterial lipopolysaccharide | downregulation of mPro mRNA expression in the bladder, upregulation of inducible nitric oxide synthase, cyclooxygenase-2, interferon-gamma, TNF-alpha, IL-1beta, and IL-6 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16651 | - |
- |
Homo sapiens | Q16651 | precursor | - |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
standard method | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | - |
Mus musculus | - |
epithelial cell | - |
Mus musculus | - |
LNCaP cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
urothelium | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
CAP-1 | - |
Homo sapiens |
prostasin/PRSS8 | - |
Homo sapiens |