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Literature summary for 3.4.21.B28 extracted from

  • Keane, F.M.; Yao, T.W.; Seelk, S.; Gall, M.G.; Chowdhury, S.; Poplawski, S.E.; Lai, J.H.; Li, Y.; Wu, W.; Farrell, P.; Vieira de Ribeiro, A.J.; Osborne, B.; Yu, D.M.; Seth, D.; Rahman, K.; Haber, P.; Topaloglu, A.K.; Wang, C.; Thomson, S.; Hennessy, A.; Prins, J.; Twigg, S.M.; McLennan, S.V.; McCaughan, G.W.; Ba, B.a.c.
    Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs (2013), FEBS open bio, 4, 43-54.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B28

Protein Variants

Protein Variants Comment Organism
additional information generation of FAP gene knockout mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Papio sp.
-
-
extracellular
-
 Mus musculus
-
-
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q12844
-
-
Mus musculus P97321
-
-
Papio sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Papio sp.
-
bladder
-
 Papio sp.
-
blood serum
-
 Papio sp.
-
blood serum
-
 Mus musculus
-
blood serum
-
 Homo sapiens
-
brain lowenzyme activity Mus musculus
-
carcinoma cell
-
 Papio sp.
-
carcinoma cell
-
 Mus musculus
-
carcinoma cell
-
 Homo sapiens
-
colon
-
 Papio sp.
-
epididymis
-
 Papio sp.
-
leukocyte lowenzyme activity Mus musculus
-
liver the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver Mus musculus
-
liver the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver Homo sapiens
-
liver the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. The enzyme activity is 14 to 18fold greater in cirrhotic than in non-diseased human liver, and almost doubled in alcoholic cirrhosis Papio sp.
-
mesenchymal cell the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver Mus musculus
-
mesenchymal cell the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver Papio sp.
-
mesenchymal cell the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver Homo sapiens
-
additional information the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver. Highest levels of enzyme activity occur in uterus, pancreas, submaxillary gland and skin, whereas the lowest levels ar found in brain, prostate, leukocytes and testis Mus musculus
-
additional information the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver Homo sapiens
-
additional information the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. The enzyme activity is greatly elevated in tumours and associated lymph nodes and in fungal-infected skin of unhealthy baboons Papio sp.
-
nerve
-
 Papio sp.
-
pancreas high enzyme activity Mus musculus
-
prostate lowenzyme activity Mus musculus
-
skin
-
 Papio sp.
-
skin high enzyme activity Mus musculus
-
submaxillary gland high enzyme activity Mus musculus
-
testis lowenzyme activity Mus musculus
-
tongue
-
 Papio sp.
-
uterus high enzyme activity Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Papio sp. Boc-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
Boc-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Boc-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
Boc-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Boc-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
Gly-Pro-7-amido-4-methylcoumarin + H2O
-
 Papio sp. Gly-Pro + 7-amino-4-methylcoumarin
-
 ?
Gly-Pro-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Gly-Pro + 7-amino-4-methylcoumarin
-
 ?
Gly-Pro-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Gly-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
FAP-specific protease
-
 Papio sp.
FAP-specific protease
-
 Mus musculus
FAP-specific protease
-
 Homo sapiens
fibroblast activation protein-specific protease
-
 Papio sp.
fibroblast activation protein-specific protease
-
 Mus musculus
fibroblast activation protein-specific protease
-
 Homo sapiens