Literature summary for 3.4.21.26 extracted from

Szeltner, Z.; Rea, D.; Renner, V.; Fulop, V.; Polgar, L.
Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site (2002), J. Biol. Chem., 277, 42613-42622.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
wild-type enzyme, mutant enzyme Y473F, mutant enzyme Y473F + benzyloxcarbonyl-Pro-prolinal and mutant enzyme S554A + succinyl-Gly-Pro-OH	Sus scrofa

Protein Variants

Protein Variants	Comment	Organism
Y473F	catalysis by the wild-type enzyme exhibits positive activation entropy. In contrast the activation entropy for the mutant enzyme is negative	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	P23687	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2 + H2O	-	Sus scrofa	2-aminobenzoyl-Gly-Phe-Gly-Pro + Phe-Gly-Phe(NO2)-Ala-NH2	-	?
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O	-	Sus scrofa	benzyloxycarbonyl-Gly-Pro + beta-naphthylamine	-	?

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Release 2023.1 (January 2023)