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Literature summary for 3.4.19.6 extracted from

  • Ramirez-Exposito, M.; Martinez-Martos, J.
    High cholesterol intake modifies pyroglutamyl aminopeptidase activity in serum and different tissues of male and female mice (2017), Curr. Top. Pept. Protein Res., 18, 103-108 .
No PubMed abstract available
Search for more literature for 3.4.19.6

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane soluble and membrane-bound forms. Membrane-bound activity is highest in kidney, heart (atrium and ventricle) and liver, the lowest activities is observed in testis and lung Mus musculus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thyrotrophin-releasing hormone + H2O Mus musculus
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 L-pyroglutamate + ?
-
 ?
TRH-like peptide + H2O Mus musculus
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 L-pyroglutamate + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9UKU6
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-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Mus musculus
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breast
-
 Mus musculus
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heart atrium and ventricle Mus musculus
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kidney
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 Mus musculus
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liver
-
 Mus musculus
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lung
-
 Mus musculus
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ovary
-
 Mus musculus
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testis
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-pyroglutamyl-beta-naphthylamide + H2O
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 Mus musculus L-pyroglutamate + 2-naphthylamine
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 ?
thyrotrophin-releasing hormone + H2O
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 Mus musculus L-pyroglutamate + ?
-
 ?
TRH-like peptide + H2O
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 Mus musculus L-pyroglutamate + ?
-
 ?

Synonyms

Synonyms Comment Organism
PAP type II
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 Mus musculus

General Information

General Information Comment Organism
metabolism high cholesterol intake modifies pyroglutamyl aminopeptidase activity in serum and different tissues of male and female mice. High cholesterol alters the regulation of this activity on their specific biologically active peptide substrates, mainly TRH and TRH-like peptides, and modifies their specific functions on target organs. Cholesterol administration in females significantly increases membrane-bound pyroglutamyl aminopeptidase-specific activity in liver by 62.03%, but significantly decreases activity in atrium by 56.56% Mus musculus