Protein Variants | Comment | Organism |
---|---|---|
C132A | site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme | Homo sapiens |
C152A | site-directed mutagenesis, removal of the C152 thiol group by mutation renders the protein refractory to attack by 15-deoxy-DELTA12,14-prostaglandin J2 | Homo sapiens |
C201A | site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme | Homo sapiens |
C220A | site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme | Homo sapiens |
C47A | site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme | Homo sapiens |
C90A | site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme | Homo sapiens |
I93M | the UCH-L1 mutant is associated with Parkinson's disease. The mutant enzyme protein is well-folded, structurally similar to the wild-type protein, and aggregates upon conjugation by cyclopentenone prostaglandins | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
15-deoxy-DELTA12,14-prostaglandin J2 | modification of UCH-L1 by cyclopentenone prostaglandins causes unfolding and aggregation. A single thiol group on Cys152 reacts with the alpha,beta-unsaturated carbonyl center in the cyclopentenone ring of prostaglandins, resulting in a covalent adduct, spectral analysis, overview | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25902 | - |
x * 25902, UCH-L1, mass spectrometry | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | UCH-L1 is present in neurofibrillary tangles or Lewy bodies | Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 25902, UCH-L1, mass spectrometry | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
UCH-L1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | UCH-L1 is implicated in Parkinsons disease and is present in neurofibrillary tangles or Lewy bodies | Homo sapiens |