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Literature summary for 3.4.17.23 extracted from

  • de Bruin, N.; Schneider, A.K.; Reus, P.; Talmon, S.; Ciesek, S.; Bojkova, D.; Cinatl, J.; Lodhi, I.; Charlesworth, B.; Sinclair, S.; Pennick, G.; Laughey, W.F.; Gribbon, P.; Kannt, A.; Schiffmann, S.
    Ibuprofen, flurbiprofen, etoricoxib or paracetamol do not influence ACE2 expression and activity in vitro or in mice and do not exacerbate in-vitro SARS-CoV-2 infection (2022), Int. J. Mol. Sci., 23, 1049 .
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information ACE2 activity in plasma is not altered by ibuprofen treatment Mus musculus
additional information ACE2 activity is not regulated by ibuprofen, flurbiprofen, etoricoxib or paracetamol Homo sapiens

Application

Application Comment Organism
medicine values of 438.1 and 219 microM ibuprofen as well as 204.7 microM flurbiprofen significantly reduce viral load in Caco-2 cells, while etoricoxib and paracetamol have no consistent, significant effect on viral load Homo sapiens
medicine values of 438.1 and 219 microM ibuprofen as well as 204.7 microM flurbiprofen significantly reduce viral load in Caco-2 cells, while etoricoxib and paracetamol have no consistent, significant effect on viral load Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information ACE2 activity is not regulated by ibuprofen, flurbiprofen, etoricoxib or paracetamol Homo sapiens
additional information ACE2 activity in plasma is not altered by ibuprofen treatment Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-
Mus musculus Q8R0I0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-

Expression

Organism Comment Expression
Mus musculus ACE2 mRNA and protein expression in murine lung, heart and aorta is not influenced by ibuprofen additional information
Homo sapiens presence of ibuprofen, flurbiprofen, etoricoxib or paracetamol have no effect on ACE2 mRNA/protein expression and activity in the Caco-2 cell model additional information