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Literature summary for 3.4.17.23 extracted from

  • Kiseleva, A.A.; Troisi, E.M.; Hensley, S.E.; Kohli, R.M.; Epstein, J.A.
    SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2 (2021), J. Biochem., 170, 299-306 .
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
SARS-CoV-2 ACE2 cleavage of des-Arg9-bradykinin substrate analogue is markedly accelerated by SARS-CoV-2 infection, while cleavage of angiotensin II analogue is minimally affected by the binding of spike protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O cleavage of angiotensin II analogue is minimally affected by the binding of the SARS-CoV-2 spike protein Homo sapiens angiotensin(1-7) + L-Phe
-
 ?
des-Arg9-bradykinin + H2O ACE2 cleavage of des-Arg9-bradykinin substrate analogue is markedly accelerated by SARS-CoV-2 infection Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ACE2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function ACE2 functions as a carboxypeptidase that can cleave several endogenous substrates, including angiotensin II, thus regulating blood pressure and vascular tone Homo sapiens
physiological function SARS-CoV-2 utilizes angiotensin-converting enzyme 2 (ACE2) as the receptor required for viral entry Homo sapiens