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Literature summary for 3.4.17.23 extracted from

  • Aleksova, A.; Gagno, G.; Sinagra, G.; Beltrami, A.P.; Janjusevic, M.; Ippolito, G.; Zumla, A.; Fluca, A.L.; Ferro, F.
    Effects of SARS-CoV-2 on cardiovascular system the dual role of angiotensin-converting enzyme 2 (ACE2) as the virus receptor and homeostasis regulator-review (2021), Int. J. Mol. Sci., 22, 4526 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
membrane type I transmembrane metallocarboxypeptidase Homo sapiens 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar cell type 2 Homo sapiens
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gastrointestinal tract
-
 Homo sapiens
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kidney renal tubular epithelium Homo sapiens
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Leydig cell
-
 Homo sapiens
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testis
-
 Homo sapiens
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vascular endothelial cell
-
 Homo sapiens
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Synonyms

Synonyms Comment Organism
ACE2
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 Homo sapiens

General Information

General Information Comment Organism
physiological function angiotensin-converting enzyme 2 (ACE2) is the entry receptor for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of Coronavirus Disease-2019 (COVID-19) in humans. ACE2 mediates the interaction between host cells and SARS-CoV-2 spike (S) protein. ACE2 is also an important homeostatic function regulating renin-angiotensin system (RAS), which is pivotal for both the cardiovascular and immune systems. ACE2 is the key link between SARS-CoV-2 infection, cardiovascular diseases (CVDs) and immune response Homo sapiens