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Literature summary for 3.4.17.23 extracted from

  • Zhang, Y.; Niu, G.; Flisikowska, T.; Schnieke, A.; Flisikowski, K.
    A tissue- and gender-specific regulation of the SARS-CoV-2 receptor ACE2 by p53 in pigs (2021), Biochem. Biophys. Res. Commun., 553, 25-29 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Sus scrofa B1PZW5
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-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Sus scrofa
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colon
-
 Sus scrofa
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esophagus
-
 Sus scrofa
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fibroblast primary kidney fibroblast Sus scrofa
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heart
-
 Sus scrofa
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kidney
-
 Sus scrofa
-
liver
-
 Sus scrofa
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lung
-
 Sus scrofa
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lymph node
-
 Sus scrofa
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muscle
-
 Sus scrofa
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small intestine
-
 Sus scrofa
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spleen
-
 Sus scrofa
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stomach
-
 Sus scrofa
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Synonyms

Synonyms Comment Organism
ACE2
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 Sus scrofa

Expression

Organism Comment Expression
Sus scrofa TP53 mutant pigs exhibit a sex-specific patho-phenotype due to altered regulation of numerous X chromosome genes. The effect of p53 deficiency on ACE2 expression in pigs is explored. The p53 binding site in the ACE2 promoter is identified and its regulatory effect on ACE2 expression is demonstrated by luciferase assay in porcine primary kidney fibroblast cells. Quantitative PCR and western blot shows tissue- and gender-specific expression changes of ACE2 and its truncated isoform in p53-deficient pigs. mRNA expression of ACE2 is higher in female than male wild-type pigs, with the highest levels in the kidney and small intestine. However, the ACE2 protein expression in the kidney and small intestine is higher in wild-type males. This discrepancy can be explained by the posttranslational ACE2 modifications. In flTP53(R167H) females, the expression of the full-length ACE2 isoform is higher than in wild-type females in most tissues, particularly in small intestine and kidney. In flTP53R167H males, the expression of ACE2 is higher in heart, kidney and lower in small intestine than in wild-type males up