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Literature summary for 3.13.2.1 extracted from
- Selection and characterization of a murine lymphoid cell line partially deficient in S-adenosylhomocysteine hydrolase (1983), Biochim. Biophys. Acta, 762, 205-214.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0004 | - |
adenosine | mutant Sahn 12 enzyme | Mus musculus |  |
| 0.00042 | - |
adenosine | wild-type R 1.1 | Mus musculus | |
| 0.156 | - |
L-homocysteine | mutant Sahn 12 | Mus musculus | |
| 0.163 | - |
L-homocysteine | wild-type R 1.1 | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | Mus musculus | - |
adenosine + L-homocysteine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| R 1.1: 378fold, 483fold: Sahn 12 | Mus musculus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine | reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adult T-cell lymphoma cell | cell line R 1.1: wild-type, Sahn 12: mutant clone | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00072 | 0.00089 | mutant Sahn 12 enzyme, crude or dialyzed cell extracts | Mus musculus |
| 0.0068 | 0.0075 | wild-type R 1.1 enzyme, crude or dialyzed cell extracts | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | - |
Mus musculus | adenosine + L-homocysteine | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
R 1.1 and Sahn 12 enzymes | Mus musculus |
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