Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | C5H5C4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blastoderm | expression of Notum1a first appears around the blastoderm margin prior to the onset of gastrulation | Danio rerio | - |
central nervous system | at 24 h post fertilization, expression is particularly pronounced in the central nervous system, including the dorsal neural tube and the midbrain-hindbrain boundary | Danio rerio | - |
embryo | - |
Danio rerio | - |
neural plate | Notum1a is expressed in the lateral edges and midline of the posterior neural plate. During segmentation, it is expressed in stripes at the lateral edges and adjacent to the midline of the neural plate | Danio rerio | - |
Synonyms | Comment | Organism |
---|---|---|
Notum 1a | - |
Danio rerio |
Organism | Comment | Expression |
---|---|---|
Danio rerio | Notum1a expression requires Wnt/beta-catenin signaling | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Notum1a contributes to a self-regulatory loop that restricts Wnt/betA-catenin signaling. Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity pathway, but plays specific role in the developing vertebrate embryo. In cultured cells, Notum1a inhibits Wnt/beta-catenin signaling | Danio rerio |