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Literature summary for 2.8.2.1 extracted from

  • Hashimoto, K.; Zaitseva, I.N.; Bonala, R.; Attaluri, S.; Ozga, K.; Iden, C.R.; Johnson, F.; Moriya, M.; Grollman, A.P.; Sidorenko, V.S.
    Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells (2016), Carcinogenesis, 37, 647-655 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Pentachlorophenol significantly reduces cell death and aristolactam-DNA adduct levels in HK-2 cells following exposure to aristolochic acid I and N-hydroxyaristolactam I Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50225 isoform SULT1A1
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Source Tissue

Source Tissue Comment Organism Textmining
GM00637 cell
-
 Homo sapiens
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HK-2 cell
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + N-hydroxyaristolactam I
-
 Homo sapiens adenosine 3',5'-bisphosphate + N-hydroxyaristolactam I sulfate
-
 ?

General Information

General Information Comment Organism
metabolism silencing of SULT1A1 and 3'-phosphoadenosine-5'-phosphosulfate synthase 2 leads to a significant decrease in aristolactam-DNA levels following exposure to aristolochic acid I. In GM00637 cells exposed to N-hydroxyaristolactam I, suppressing the sulfotransferase pathway leads to a significant decrease in aristolactam-DNA adduct formation Homo sapiens