Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a target for treatment of Huntigton disease | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens | |
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | Homo sapiens | overall reaction | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? | |
ATP + GTP | Mus musculus | overall reaction | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? | |
ATP + GTP | Mus musculus C57BL/6J | overall reaction | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N884 | - |
- |
Mus musculus | Q8C6L5 | - |
- |
Mus musculus C57BL/6J | Q8C6L5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corpus striatum | - |
Homo sapiens | - |
striatal neuron | - |
Homo sapiens | - |
striatal neuron | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | overall reaction | Homo sapiens | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? | |
ATP + GTP | overall reaction | Mus musculus | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? | |
ATP + GTP | overall reaction | Mus musculus C57BL/6J | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGAS | - |
Homo sapiens |
cGAS | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of cGAS diminishes cGAS activity and decreases the expression of inflammatory genes while suppressing the upregulation of autophagy in Huntington disease (HD) cells, while reinstating cGAS in cGAS-depleted HD cells activates cGAS activity and promotes inflammatory and autophagy responses. Phenotype, overview | Homo sapiens |
malfunction | depletion of cGAS diminishes cGAS activity and decreases the expression of inflammatory genes while suppressing the upregulation of autophagy in Huntington disease (HD) cells, while reinstating cGAS in cGAS-depleted HD cells activates cGAS activity and promotes inflammatory and autophagy responses. Phenotype, overview | Mus musculus |
physiological function | cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease (HD). cGMP-AMP synthase (cGAS), a DNA sensor, is a critical regulator of inflammatory and autophagy responses in HD. Ribosome profiling reveals that the cGAS mRNA has high ribosome occupancy at exon 1 and codon-specific pauses at positions 171 (CCG) and 172 (CGT) in HD striatal cells. The protein levels and activity of cGAS (based on the phosphorylated STING and phosphorylated TBK1 levels), and the expression and ribosome occupancy of cGAS-dependent inflammatory genes (Ccl5 and Cxcl10) are increased in HD striatum. Phenotype, overview | Mus musculus |
physiological function | cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease (HD). cGMP-AMP synthase (cGAS), a DNA sensor, is a critical regulator of inflammatory and autophagy responses in HD. Ribosome profiling reveals that the cGAS mRNA has high ribosome occupancy at exon 1 and codon-specific pauses at positions 171 (CCG) and 172 (CGT) in HD striatal cells. The protein levels and activity of cGAS (based on the phosphorylated STING and phosphorylated TBK1 levels), and the expression and ribosome occupancy of cGAS-dependent inflammatory genes (Ccl5 and Cxcl10) are increased in HD striatum. The two major autophagy initiators, LC3A and LC3B, may be differentially regulated via cotranslational proteolytic events to initiate autophagy, which might additionally contribute to the cGAS-mediated autophagy in HD. Phenotype, overview | Homo sapiens |