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Literature summary for 2.7.7.86 extracted from

  • Abdisalaam, S.; Bhattacharya, S.; Mukherjee, S.; Sinha, D.; Srinivasan, K.; Zhu, M.; Akbay, E.A.; Sadek, H.A.; Shay, J.W.; Asaithamby, A.
    Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase (2020), J. Biol. Chem., 295, 11144-11160 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.86

Cloned(Commentary)

Cloned (Comment) Organism
gene CGAS, quantitative real-time PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one RU-521 or RU.521 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
micronucleus telomeric DNA and cGAS are co-localized in a limited number of micronuclei Homo sapiens 31040
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Homo sapiens overall reaction 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N884
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BEAS-2B cell
-
 Homo sapiens
-
fibroblast immortalized 82-6 fibroblasts Homo sapiens
-
HT-1080 cell
-
 Homo sapiens
-
IMR-90 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP overall reaction Homo sapiens 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?

Synonyms

Synonyms Comment Organism
cGAS
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism cellular intrinsic mechanism involving the cGAS-mediated cytosolic self-DNA-sensing pathway that initiates premature senescence independently of telomere shortening, overview. Micronuclei generated in response to telomeric DNA replication stress recruit cGAS and cause cellular senescence Homo sapiens
physiological function dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase. Cyclic GMP-AMP synthase (cGAS) recognizing cytosolic chromatin fragments and then activating the stimulator of interferon genes (STING) cytosolic DNA-sensing pathway and downstream interferon signaling. Significantly, genetic and pharmacological manipulation of cGAS not only attenuates immune signaling, but also prevents premature cellular senescence in response to dysfunctional telomeres. cGAS causes premature senescence phenotype in response to dysfunctional telomeres, cGAS-STING-TBK1-IRF3 signaling, mechanism, overview Homo sapiens