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Literature summary for 2.7.4.6 extracted from

  • Lacombe, M.L.; Tokarska-Schlattner, M.; Boissan, M.; Schlattner, U.
    The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis (2018), Lab. Invest., 98, 582-588 .
    View publication on PubMed
Search for more literature for 2.7.4.6

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O00746
-
-
Mus musculus Q9WV84
-
-
Xenopus laevis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder high expression Homo sapiens
-
brain low expression Homo sapiens
-
colon intermediate expression Homo sapiens
-
heart intermediate expression Homo sapiens
-
heart much lower NME4 mRNA level than the NME1 and NME2 counterparts Mus musculus
-
hepatoma cell in hepatocarcinoma derived cell lines, NME4 expression is lower in cell lines with high metastatic potential Homo sapiens
-
intestine intermediate expression Homo sapiens
-
kidney high expression Homo sapiens
-
kidney much lower NME4 mRNA level than the NME1 and NME2 counterparts Mus musculus
-
leukocyte low expression Homo sapiens
-
liver high expression Homo sapiens
-
liver much lower NME4 mRNA level than the NME1 and NME2 counterparts Mus musculus
-
ovary intermediate expression Homo sapiens
-
prostate gland high expression Homo sapiens
-
skeletal muscle intermediate expression Homo sapiens
-
testis low expression Homo sapiens
-

Synonyms

Synonyms Comment Organism
NDPK-D
-
 Homo sapiens
NDPK-D
-
 Mus musculus
NM23-H4
-
 Homo sapiens
NM23-H4
-
 Mus musculus
NME4
-
 Xenopus laevis
NME4
-
 Homo sapiens
NME4
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens overexpression of NME4 mRNA in several types of tumors up

General Information

General Information Comment Organism
physiological function the mitochondrial NME4 protein has multiple functions in bioenergetics and phospholipid signaling. It acts as a cardiolipin-dependent mitochondrial switch between a phosphotransfer function serving local GTP supply and a cardiolipin transfer function for signaling apoptosis, mitophagy and putative other cellular processes. It can fuel GTP to the dynamin-like GTPase OPA1 and thus regulate mitochondrial dynamics. Independently of its kinase activity, NDPK-D/NME4 can promote the intermembrane cardiolipin transfer to the mitochondrial surface. Under these conditions, it promotes apoptosis to eliminate damaged cells or mitophagy to eliminate damaged mitochondria, both important quality control mechanisms. NDPK-D is a key player in the control of cell homeostasis and an important contributor to the quality control of mitochondria Homo sapiens
physiological function the mitochondrial NME4 protein has multiple functions in bioenergetics and phospholipid signaling. It acts as a cardiolipin-dependent mitochondrial switch between a phosphotransfer function serving local GTP supply and a cardiolipin transfer function for signaling apoptosis, mitophagy and putative other cellular processes. It can fuel GTP to the dynamin-like GTPase OPA1 and thus regulate mitochondrial dynamics. Independently of its kinase activity, NDPK-D/NME4 can promote the intermembrane cardiolipin transfer to the mitochondrial surface. Under these conditions, it promotes apoptosis to eliminate damaged cells or mitophagy to eliminate damaged mitochondria, both important quality control mechanisms. NDPK-D is a key player in the control of cell homeostasis and an important contributor to the quality control of mitochondria Mus musculus