Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p25 | cyclin activator, dependent on, over 10fold increase in activity of CDK5 | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Mus musculus | hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview | ADP + O-phospho-[tau-protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain cortex | - |
Mus musculus | - |
central nervous system | - |
Mus musculus | - |
CN1.4 cell | immortilized embryonic brain cortex cell line | Mus musculus | - |
embryo | - |
Mus musculus | - |
HTAU cell | immortilized embryonic brain cortex cell line overexpressing the human tau protein | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | phosphorylation of the PHF-1 epitope at Ser396 and Ser404 by CDK5 | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk5 | - |
Mus musculus |
CDK5/p25 | - |
Mus musculus |
cyclin-dependent kinase-5 | - |
Mus musculus |
More | CDK5 is a unique member of the CDK family, see also EC 2.7.11.22 | Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |