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Literature summary for 2.7.1.68 extracted from

  • Wu, P.F.; Bhore, N.; Lee, Y.L.; Chou, J.Y.; Chen, Y.W.; Wu, P.Y.; Hsu, W.M.; Lee, H.; Huang, Y.S.; Lu, P.J.; Liao, Y.F.
    Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein (2020), FASEB J., 34, 12127-12146 .
    View publication on PubMed
Search for more literature for 2.7.1.68

Protein Variants

Protein Variants Comment Organism
D309N inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortical neuron
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 68000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PIP5K
-
 Homo sapiens
PIP5K type Ialpha
-
 Homo sapiens
PIP5K1A
-
 Homo sapiens
type 1 phosphatidylinositol-4-phosphate 5-kinase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function overexpression of isoform PIP5K1A results in significant enhancement of non-amyloidogenic amyloid precursor protein processing and a concomitant suppression of the amyloidogenic pathway, leading to a marked decrease in secreted amyloid-beta peptide Homo sapiens