Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60331 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDCK cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PIPKIgamma | - |
Homo sapiens |
type Igamma phosphatidylinositol 4-phosphate 5-kinase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme interacts with the cytoskeleton regulator IQGAP1 and modulates IQ motif containing GTPase activating protein 1 (IQGAP1) function in migration. The enzyme is required for IQGAP1 recruitment to the leading edge membrane in response to integrin or growth factor receptor activation | Homo sapiens |