Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of single knockout mutants of isozymes Pip5k1a and Pip5k1b, and double knockout mutants | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozymes PIP5K1A, PIP5K1B, and PIP5K1C | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
sperm | - |
Mus musculus | - |
spermatocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 4-phosphate 5-kinase | - |
Mus musculus |
PIP5K | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockoout mutants are infertile, phenotypes, overview. Flagella of sperm from isozyme Pip5k1a knockout mutant and even more of Pip5k1a/Pip5k1b double-knockout mutant mice remarkably undergo morphological changes and impairment, whereas Pip5k1b-knockout mutant sperm is morphologically normal. F-actin organization in the seminiferous epithelium is disrupted by the loss of PIP5K1A and PIP5K1B | Mus musculus |
physiological function | the lipid kinase phosphatidylinositol 4-phosphate 5-kinase produces a versatile signaling phospholipid, phosphatidylinositol 4,5-bisphosphate, isozymes PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis | Mus musculus |